Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes.

نویسندگان

  • Shuo-Bin Chen
  • Wei-Bin Wu
  • Ming-Hao Hu
  • Tian-Miao Ou
  • Lian-Quan Gu
  • Jia-Heng Tan
  • Zhi-Shu Huang
چکیده

A novel 2,4,5-triaryl-substituted imidazole (IZCM-1) has been found to display distinct and specific fluorescence enhancement upon binding to parallel G-quadruplexes. Such a sensitive and topology-specific probe is able to light up without affecting the topology or thermal stability of the G-quadruplex sample. Thus, these advantages distinguish IZCM-1 from other G-quadruplex probes.

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عنوان ژورنال:
  • Chemical communications

دوره 50 81  شماره 

صفحات  -

تاریخ انتشار 2014